Exploiting Apoptosis for Therapeutic Tolerance Induction
نویسندگان
چکیده
منابع مشابه
Exploiting apoptosis for therapeutic tolerance induction.
Immune tolerance remains the most promising yet elusive strategy for treating immune-mediated diseases. An experimental strategy showing promise in phase 1 clinical studies is the delivery of Ag cross-linked to apoptotic leukocytes using ethylene carbodiimide. This approach originated from demonstration of the profound tolerance-inducing ability of i.v. administered Ag-coupled splenocytes (Ag-S...
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Immunological tolerance can be defined as an unresponsiveness of T and/or B cells to self antigens. Low responsiveness of T cells and/or B cells to self antigens could be termed partial tolerance. Protection from the development of autoimmune diseases and acceptance of transplanted organs or tissue are due to effective tolerance to self antigens and alloantigens, respectively. The breakdown of ...
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Dendritic cells (DCs) are major players in the control of adaptive tolerance and immunity. Therefore, their specific generation and adoptive transfer into patients or their in vivo targeting is attractive for clinical applications. While injections of mature immunogenic DCs are tested in clinical trials, tolerogenic DCs still are awaiting this step. Besides the tolerogenic potential of immature...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2013
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1302070